Relatm1.1Gho
Targeted Allele Detail
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Symbol: |
Relatm1.1Gho |
Name: |
v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1.1, Sankar Ghosh |
MGI ID: |
MGI:3794987 |
Synonyms: |
p65-S276A(RRPA) |
Gene: |
Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
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Alliance: |
Relatm1.1Gho page
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Germline Transmission: |
Earliest citation of germline transmission:
J:134684
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: By homologous recombination in ES cells, endogenous DNA sequence for the serine 276 residue in exon 7 of Rela gene was replaced with codon for alanine followed by a neo cassette flanked by two loxP sites inserted into intron after Exon 7. A neo cassette was then deleted either in the recombined ES cells by transfection of cre-recombinase or in mice by crossing with splicer mice harboring a Cre transgene, leaving only single loxP sites. The presence of the mutation was confirmed by Northern blot, RT-PCR and DNA sequencing.
(J:134684)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rela Mutation: |
28 strains or lines available
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Original: |
J:134684 Dong J, et al., Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms. Genes Dev. 2008 May 1;22(9):1159-73 |
All: |
1 reference(s) |
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