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Relatm1.1Gho
Targeted Allele Detail
Summary
Symbol: Relatm1.1Gho
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1.1, Sankar Ghosh
MGI ID: MGI:3794987
Synonyms: p65-S276A(RRPA)
Gene: Rela  Location: Chr19:5687511-5698158 bp, + strand  Genetic Position: Chr19, 4.34 cM, cytoband B1-3
Alliance: Relatm1.1Gho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134684
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsBy homologous recombination in ES cells, endogenous DNA sequence for the serine 276 residue in exon 7 of Rela gene was replaced with codon for alanine followed by a neo cassette flanked by two loxP sites inserted into intron after Exon 7. A neo cassette was then deleted either in the recombined ES cells by transfection of cre-recombinase or in mice by crossing with splicer mice harboring a Cre transgene, leaving only single loxP sites. The presence of the mutation was confirmed by Northern blot, RT-PCR and DNA sequencing. (J:134684)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rela Mutation:  28 strains or lines available
References
Original:  J:134684 Dong J, et al., Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms. Genes Dev. 2008 May 1;22(9):1159-73
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory