Stat3^tm1Jbha
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1Jbha
• Name: signal transducer and activator of transcription 3; targeted mutation 1, Joyce B Harp
• MGI ID: MGI:3795149
• Synonyms: STAT3^flox
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1Jbha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136030
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream and downstream of exon 22. An frt-flanked neo cassette was inserted downstream of exon 22 and was removed by transient flp-mediated recombination in ES cells. (J:136030)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:136030 Cernkovich ER, et al., Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology. 2008 Apr;149(4):1581-90
• All: 1 reference(s)