Tg(Itgax-TGFBR2)1Flv
Transgene Detail
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Symbol: |
Tg(Itgax-TGFBR2)1Flv |
Name: |
transgene insertion 1, Richard A Flavell |
MGI ID: |
MGI:3795208 |
Synonyms: |
CD11cdnR, Cd11cdnTGFBR2, CD11c-dnTGFBRII |
Transgene: |
Tg(Itgax-TGFBR2)1Flv Location: unknown
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Alliance: |
Tg(Itgax-TGFBR2)1Flv page
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Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Itgax-TGFBR2)1Flv expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
TGFBR2 (7048) |
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Mutation details: The human TGFBRIII (Tgfbr2 transforming growth factor, beta receptor II) gene sequence between nucleotides -7 to +573 encoding the extracellular and transmembrane regions of TGFBR2 (dominant negative, dnTGFBR2) was inserted into exon 3 of the rabbit beta globin gene in the plasmid Itgax promoter vector pDOI-5. The construct was injected into (C57BL/6 x C3H)F1 hybrid fertilized eggs. RT-PCR confirmed expression of dnTGFBR2 in Itgax (CD11c)-expressing cells including subsets of natural killer cell (NK) and dendritic cell (DC) subsets. No expression is detected in NKT cells, T cells or B cells. Expression is sufficient to block TFG beta signaling through the functional receptor exclusively in DCs and NK cells.
(J:98953)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:98953 Laouar Y, et al., Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma. Nat Immunol. 2005 Jun;6(6):600-7 |
All: |
14 reference(s) |
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