Tg(GPD1)A2Bir
Transgene Detail

Summary

• Symbol: Tg(GPD1)A2Bir
• Name: transgene insertion A2, Edward H Birkenmeier
• MGI ID: MGI:3795211
• Synonyms: GPDH-A2
• Transgene: Tg(GPD1)A2Bir Location: unknown
• Alliance: Tg(GPD1)A2Bir page

Transgene origin

• Strain of Origin: (C57BL/6J x LT/Sv)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GPD1)A2Bir expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GPD1 (2819)

  Gpd1	(MGI:95679)

• Mutation details: The transgene comprises 12.3 kb of human genomic DNA containing the GPD1 gene, consisting of 3.5 kb of 5' flanking sequence, the 7.6 kb protein-coding region and 1.2 kb of 3' flanking DNA. The 5' flanking sequence includes the proximal and distal promoter regions. Founder line A2 has approximately 14 copies of the transgene. Mice exhibit a much higher level of transgene expression in the cerebral cortex and kidney than is normal for the endogenous gene. (J:135002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:135002 Birkenmeier EH, et al., Tissue- and cell-specific expression of human sn-glycerol-3-phosphate dehydrogenase in transgenic mice. Nucleic Acids Res. 1992 Jun 11;20(11):2819-25
• All: 1 reference(s)