Sox8^tm1Mkob
Targeted Allele Detail

Summary

• Symbol: Sox8^tm1Mkob
• Name: SRY (sex determining region Y)-box 8; targeted mutation 1, Moira K O'Bryan
• MGI ID: MGI:3795214
• Gene: Sox8 Location: Chr17:25784865-25789666 bp, - strand Genetic Position: Chr17, 12.69 cM
• Alliance: Sox8^tm1Mkob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136098
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 through 2 was replaced with a lacZ gene and floxed neo cassette. The neo cassette was removed by germ line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on testis extracts. This is a null allele and a reporter allele. (J:136098)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox8 Mutation: 28 strains or lines available

References

• Original: J:136098 O'Bryan MK, et al., Sox8 is a critical regulator of adult Sertoli cell function and male fertility. Dev Biol. 2008 Apr 15;316(2):359-70
• All: 4 reference(s)