Serpina10^tm1Gjb
Targeted Allele Detail

Summary

• Symbol: Serpina10^tm1Gjb
• Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10; targeted mutation 1, George J Broze
• MGI ID: MGI:3795215
• Synonyms: ZPI^-
• Gene: Serpina10 Location: Chr12:103582934-103597681 bp, - strand Genetic Position: Chr12, 52.97 cM
• Alliance: Serpina10^tm1Gjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136102
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on mouse plasma extracts. (J:136102)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpina10 Mutation: 23 strains or lines available

References

• Original: J:136102 Zhang J, et al., Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency. Blood. 2008 May 15;111(10):4973-8
• All: 3 reference(s)