Slc12a1^tm1Haca
Targeted Allele Detail

Summary

• Symbol: Slc12a1^tm1Haca
• Name: solute carrier family 12, member 1; targeted mutation 1, Hayo Castrop
• MGI ID: MGI:3795217
• Synonyms: NKCC2B^-
• Gene: Slc12a1 Location: Chr2:124994430-125071922 bp, + strand Genetic Position: Chr2, 61.23 cM
• Alliance: Slc12a1^tm1Haca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135710
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4B was replaced with a STOP and floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. Expression of the A and F alternate transcripts but not the B transcript was confirmed by RT-PCR. (J:135710)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a1 Mutation: 55 strains or lines available

References

• Original: J:135710 Oppermann M, et al., Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. J Am Soc Nephrol. 2006 Aug;17(8):2143-52
• All: 2 reference(s)