Esr1^tm1Geog
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1Geog
• Name: estrogen receptor 1 (alpha); targeted mutation 1, Geoffrey Greene
• MGI ID: MGI:3795228
• Synonyms: ENERKI, ERalpha^G525L
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1Geog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135981
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: Exon 9 was replaced with a self-excising floxed neo cassette and an exon 9 containing a nucleotide susbtitution that results in an amino acid substitution of leucine for glycine at position 525 (G525L). (J:135981)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:135981 Sinkevicius KW, et al., An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology. 2008 Jun;149(6):2970-9
• All: 4 reference(s)