Gnrhr^{tm1.1(cre)Uboe}
Targeted Allele Detail

Summary

• Symbol: Gnrhr^{tm1.1(cre)Uboe}
• Name: gonadotropin releasing hormone receptor; targeted mutation 1.1, Ulrich Boehm
• MGI ID: MGI:3795249
• Synonyms: Gnrhr^GRIC, GnRHR-IRES-Cre, GRIC, GRIC^neo-
• Gene: Gnrhr Location: Chr5:86328613-86345760 bp, - strand Genetic Position: Chr5, 43.56 cM
• Alliance: Gnrhr^{tm1.1(cre)Uboe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136037
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gnrhr^{tm1.1(cre)Uboe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gnrhr (MGI:95790)

• Mutation details: An IRES-cre and frt-flanked neo cassette were inserted downstream of exon 3. The neo cassette was removed by germ line, flp mediated recombination. (J:136037)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gnrhr (mouse) Summary of all recombinase alleles driven by Gnrhr. Alliance mouse Gnrhr gene page

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnrhr Mutation: 20 strains or lines available

References

• Original: J:136037 Wen S, et al., Functional characterization of genetically labeled gonadotropes. Endocrinology. 2008 Jun;149(6):2701-11
• All: 33 reference(s)