Cdca8^tm1Tatn
Targeted Allele Detail

Summary

• Symbol: Cdca8^tm1Tatn
• Name: cell division cycle associated 8; targeted mutation 1, Tatsutoshi Nakahata
• MGI ID: MGI:3795253
• Synonyms: borealin^-, Borealin/DasraB^-
• Gene: Cdca8 Location: Chr4:124812258-124830710 bp, - strand Genetic Position: Chr4, 57.93 cM
• Alliance: Cdca8^tm1Tatn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135988
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted through the insertion of a lacZ cDNA and a neomycin resistance cassette into exon 1. (J:135988)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdca8 Mutation: 23 strains or lines available

References

• Original: J:135988 Yamanaka Y, et al., Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev. 2008 May-Jun;125(5-6):441-50
• All: 2 reference(s)