Trp63^tm1Aam
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1Aam
• Name: transformation related protein 63; targeted mutation 1, Alea A Mills
• MGI ID: MGI:3795257
• Synonyms: p63^EEC, Trp63^R279H
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1Aam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135784
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: This allele is modified such that histidine is substituted for arginine at position 279. (details unpublished) (J:135784)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:135784 Lo Iacono N, et al., Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development. 2008 Apr;135(7):1377-88
• All: 3 reference(s)