Nr5a2^tm1Sakl
Targeted Allele Detail

Summary

• Symbol: Nr5a2^tm1Sakl
• Name: nuclear receptor subfamily 5, group A, member 2; targeted mutation 1, Steven A Kliewer
• MGI ID: MGI:3795276
• Synonyms: LRH-1^floxed
• Gene: Nr5a2 Location: Chr1:136770309-136888186 bp, - strand Genetic Position: Chr1, 59.98 cM, cytoband E4
• Alliance: Nr5a2^tm1Sakl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135822
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5 and an additional loxP site was inserted upstream of exon 5. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 5 floxed. (J:135822)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr5a2 Mutation: 96 strains or lines available

References

• Original: J:135822 Lee YK, et al., Liver receptor homolog-1 regulates bile Acid homeostasis but is not essential for feedback regulation of bile Acid synthesis. Mol Endocrinol. 2008 Jun;22(6):1345-56
• All: 9 reference(s)