Kcnn4^tm1.1Jele
Targeted Allele Detail

Summary

• Symbol: Kcnn4^tm1.1Jele
• Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; targeted mutation 1.1, Jens Leipziger
• MGI ID: MGI:3795277
• Synonyms: KCa3.1^-, SK4^-
• Gene: Kcnn4 Location: Chr7:24069750-24084635 bp, + strand Genetic Position: Chr7, 10.37 cM
• Alliance: Kcnn4^tm1.1Jele page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135743
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted dowstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Transient cre transfection in ES cells was used to remove the neo cassette and exon 2 that encodes the pore. (J:135743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnn4 Mutation: 22 strains or lines available

References

• Original: J:135743 Sausbier M, et al., Distal colonic K(+) secretion occurs via BK channels. J Am Soc Nephrol. 2006 May;17(5):1275-82
• All: 7 reference(s)