Gimap4^tm1Jcbs
Targeted Allele Detail

Summary

• Symbol: Gimap4^tm1Jcbs
• Name: GTPase, IMAP family member 4; targeted mutation 1, Heinz Jacobs
• MGI ID: MGI:3795278
• Gene: Gimap4 Location: Chr6:48661483-48668994 bp, + strand Genetic Position: Chr6, 23.66 cM
• Alliance: Gimap4^tm1Jcbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135744
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the coding region in exon 3 was replaced with a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. The absence of protein produce was confirmed by western blot analysis on lymphocyte extracts. (J:135744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gimap4 Mutation: 21 strains or lines available

References

• Original: J:135744 Schnell S, et al., Gimap4 accelerates T-cell death. Blood. 2006 Jul 15;108(2):591-9
• All: 1 reference(s)