Igk^tm1.1Cog
Targeted Allele Detail

Summary

• Symbol: Igk^tm1.1Cog
• Name: immunoglobulin kappa chain complex; targeted mutation 1.1, Michel Cogne
• MGI ID: MGI:3795280
• Synonyms: kappa-CHEB
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135758
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Igkj segments were replaced with a loxP site flanked neomycin resistance gene cassette and a human variable and joint segments that recognize CHEB with a 3' loxP site. Subsequent germ line, cre-mediated recombination was used to remove the neo cassette leaving the human variable and joint segments intact. (J:135758)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 26 strains or lines available

References

• Original: J:135758 Sirac C, et al., Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome. Blood. 2006 Jul 15;108(2):536-43
• All: 1 reference(s)