Igk^tm1.2Cog
Targeted Allele Detail

Summary

• Symbol: Igk^tm1.2Cog
• Name: immunoglobulin kappa chain complex; targeted mutation 1.2, Michel Cogne
• MGI ID: MGI:3795282
• Synonyms: kappa-del
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135758
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intergenic deletion
• Mutation details: The Igkj segments were replaced with a loxP site flanked neomycin resistance gene cassette and a human variable and joint segments that recognize CHEB with a 3' loxP site. Subsequent germ line, cre-mediated recombination was used to remove the neo cassette and the inserted human variable and joint segments. (J:135758)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 26 strains or lines available

References

• Original: J:135758 Sirac C, et al., Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome. Blood. 2006 Jul 15;108(2):536-43
• All: 2 reference(s)