Dicer1^tm1.1Mmk
Targeted Allele Detail

Summary

• Symbol: Dicer1^tm1.1Mmk
• Name: dicer 1, ribonuclease type III; targeted mutation 1.1, Matthias Merkenschlager
• MGI ID: MGI:3795355
• Synonyms: dcr^delta
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^tm1.1Mmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 20 and 21, which contain the RNaseII domain, were removed by germ line, cre-mediated recombination. No functional protein product is expected to be produced. (J:135783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:135783 Koralov SB, et al., Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74
• All: 1 reference(s)