Mirc1^tm1Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc1^tm1Tyj
• Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:3795513
• Synonyms: miR17~92^2f/2l, miR17~92^2frt/2lox
• Gene: Mirc1 Location: Chr14:115281103-115281938 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134861
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced 5' of the Mirn17 gene and 3' of the Mir92-1 gene. The floxed region was followed by an Frt-flanked neomycin cassette. The entire cluster, including Mir17, Mir18a, Mir19a, Mir20a, Mir19b-1, and Mir92-1 is flanked by the inserted loxP sites. (J:134861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc1 Mutation: 6 strains or lines available

References

• Original: J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
• All: 6 reference(s)