Mirc1^tm1.3Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc1^tm1.3Tyj
• Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 1.3, Tyler Jacks
• MGI ID: MGI:3795517
• Synonyms: miR17-393^deltaneo
• Gene: Mirc1 Location: Chr14:115281103-115281938 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134861
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Mice carrying the Mirc1^tm1Tyj (2frt/2lox) allele were crossed to mice expressing an ACTB-cre transgene to excise the floxed cluster, including Mir17, Mir18a, Mir19a, Mir20a, Mir19b-1, and Mir92-1, but leaving the Frt-flanked neomycin cassette. (J:134861)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Mirc1^tm1.3Tyj/Mirc1^tm1.3Tyj	involves: 129S4/SvJae * C57BL/6 * FVB/N

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
abnormal interventricular septum morphology	√
cellular	√
increased B cell apoptosis	√
embryo	√
decreased embryo size	√
decreased embryo weight	√
growth/size/body	√
decreased embryo size	√
decreased embryo weight	√
hematopoietic system	√
increased B cell apoptosis	√
abnormal B cell differentiation	√
decreased pre-B cell number	√
immune system	√
increased B cell apoptosis	√
abnormal B cell differentiation	√
decreased pre-B cell number	√
mortality/aging	√
neonatal lethality, complete penetrance	√
respiratory system	√
pulmonary hypoplasia	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc1 Mutation: 6 strains or lines available

References

• Original: J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
• All: 1 reference(s)