Mirc1^tm1.3Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc1^tm1.3Tyj
• Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 1.3, Tyler Jacks
• MGI ID: MGI:3795517
• Synonyms: miR17-393^deltaneo
• Gene: Mirc1 Location: Chr14:115281103-115281938 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134861
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Mice carrying the Mirc1^tm1Tyj (2frt/2lox) allele were crossed to mice expressing an ACTB-cre transgene to excise the floxed cluster, including Mir17, Mir18a, Mir19a, Mir20a, Mir19b-1, and Mir92-1, but leaving the Frt-flanked neomycin cassette. (J:134861)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc1 Mutation: 6 strains or lines available

References

• Original: J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
• All: 1 reference(s)