Pik3ca^tm3Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm3Bvan
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 3, Bart Vanhaesebroeck
• MGI ID: MGI:3795787
• Synonyms: p110alpha^flox
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm3Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136236
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 17 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 19. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 18 and 19 floxed. (J:136236)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 66 strains or lines available

References

• Original: J:136236 Graupera M, et al., Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature. 2008 May 29;453(7195):662-6
• All: 22 reference(s)