Pik3cb^tm1Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3cb^tm1Bvan
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1, Bart Vanhaesebroeck
• MGI ID: MGI:3795849
• Synonyms: p110beta^flox
• Gene: Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Pik3cb^tm1Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136305
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 21 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 22. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 21 and 22 floxed. (J:136305)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3cb Mutation: 152 strains or lines available

References

• Original: J:136305 Guillermet-Guibert J, et al., The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7
• All: 15 reference(s)