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Pik3cbtm1.1Bvan
Targeted Allele Detail
Summary
Symbol: Pik3cbtm1.1Bvan
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1.1, Bart Vanhaesebroeck
MGI ID: MGI:3795850
Synonyms: p110beta(delta21,22
Gene: Pik3cb  Location: Chr9:98920455-99022264 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance: Pik3cbtm1.1Bvan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136305
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsGerm line, cre-mediated recombination was used to remove exons 21 and 22. The absence of protein product was confirmed by immunobloting. (J:136305)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:  152 strains or lines available
References
Original:  J:136305 Guillermet-Guibert J, et al., The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory