Pik3cb^tm1.1Bvan
Targeted Allele Detail

Summary

• Symbol: Pik3cb^tm1.1Bvan
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1.1, Bart Vanhaesebroeck
• MGI ID: MGI:3795850
• Synonyms: p110beta^(delta21,22
• Gene: Pik3cb Location: Chr9:98920455-99022264 bp, - strand Genetic Position: Chr9, 51.41 cM, cytoband E4
• Alliance: Pik3cb^tm1.1Bvan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136305
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exons 21 and 22. The absence of protein product was confirmed by immunobloting. (J:136305)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Pik3cb Mutation: 152 strains or lines available

References

• Original: J:136305 Guillermet-Guibert J, et al., The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7
• All: 3 reference(s)