F3^tm1(F3)Lasn
Targeted Allele Detail

Summary

• Symbol: F3^tm1(F3)Lasn
• Name: coagulation factor III; targeted mutation 1, Linda A Snyder
• MGI ID: MGI:3795857
• Synonyms: TFKI
• Gene: F3 Location: Chr3:121517186-121528697 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: F3^tm1(F3)Lasn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 2 were replaced with human F3 and a floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. (J:133293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F3 Mutation: 24 strains or lines available

References

• Original: J:133293 Snyder LA, et al., Expression of human tissue factor under the control of the mouse tissue factor promoter mediates normal hemostasis in knock-in mice. J Thromb Haemost. 2008 Feb;6(2):306-14
• All: 4 reference(s)