Abcg4^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Abcg4^tm1Dgen
• Name: ATP binding cassette subfamily G member 4; targeted mutation 1, Deltagen
• MGI ID: MGI:3795864
• Gene: Abcg4 Location: Chr9:44184485-44199912 bp, - strand Genetic Position: Chr9, 24.84 cM, cytoband A5.3
• Alliance: Abcg4^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128847
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Bases 1,622 to 1,647 were replaced with a cassette containing a neo gene, an IRES, and a lacZ gene with a nuclear localization signal. (J:128847)

Expression

In Mice Carrying this Mutation:

69 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcg4 Mutation: 36 strains or lines available

References

• Original: J:128847 Tarr PT, et al., ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. J Lipid Res. 2008 Jan;49(1):169-82
• All: 5 reference(s)