Map3k8^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Map3k8^M1Btlr
• Name: mitogen-activated protein kinase kinase kinase 8; mutation 1, Bruce Beutler
• MGI ID: MGI:3795881
• Synonyms: sluggish
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a screen of G3 progeny of ENU mutagenized male mice for altered responses to toll-like receptor (TLR) ligands. The mutation is a T to A transversion in the acceptor splice site of intron 4 (TTGCAG --> TAGCAG), at nucleotide position 13346 of the genomic sequence (Genbank accession NC_000084). Three differently spliced transcripts have been observed in the mutant mice, one of which is similar in size to the wild type mRNA. One of the aberrant splicing events skips exon 5 and causes a frame shift. The second abnormal splicing event joins exon 3 to exon 6 in-frame, skipping exons 4 and 5.
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:140986 Xiao N, et al., Record for "Sluggish", updated November 17, 2008. MGI Direct Data Submission. 2008
• All: 2 reference(s)