Ackr3^tm1Jgo
Targeted Allele Detail

Summary

• Symbol: Ackr3^tm1Jgo
• Name: atypical chemokine receptor 3; targeted mutation 1, Jan A Gossen
• MGI ID: MGI:3796065
• Gene: Ackr3 Location: Chr1:90131702-90143446 bp, + strand Genetic Position: Chr1, 45.28 cM
• Alliance: Ackr3^tm1Jgo page

Enlarged hearts with cardiomyocyte hyperplasia, degeneration and fibrosis in some Ackr3^tm1Jgo/Ackr3^tm1Jgo mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136246
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 containing the translation initiation codon was replaced with a lacZ/neo cassette. The absence of transcript was confirmed by RT-PCR on heart extracts. Reporter gene expression was detected in cardiomyocytes, vascular endothelial cells of the lung and heart, the cerebral cortex and in the osteocytes of the bone. (J:136246)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ackr3 Mutation: 34 strains or lines available

References

• Original: J:136246 Gerrits H, et al., Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis. 2008 May;46(5):235-45
• All: 1 reference(s)