Rgs5^tm1Rgan
Targeted Allele Detail

Summary

• Symbol: Rgs5^tm1Rgan
• Name: regulator of G-protein signaling 5; targeted mutation 1, Ruth Ganss
• MGI ID: MGI:3796066
• Gene: Rgs5 Location: Chr1:169483070-169523367 bp, + strand Genetic Position: Chr1, 76.84 cM, cytoband H2
• Alliance: Rgs5^tm1Rgan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136259
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette was inserted downstream of exon 1. Germ line, flp-mediated recombination was used to remove the neo cassette. (J:136259)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs5 Mutation: 21 strains or lines available

References

• Original: J:136259 Hamzah J, et al., Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature. 2008 May 15;453(7193):410-4
• All: 1 reference(s)