Il17f^tm1Cdon
Targeted Allele Detail

Summary

• Symbol: Il17f^tm1Cdon
• Name: interleukin 17F; targeted mutation 1, Chen Dong
• MGI ID: MGI:3796155
• Synonyms: Il17^-, IL-17F-RFP, Il17^rfp
• Gene: Il17f Location: Chr1:20847370-20855498 bp, - strand Genetic Position: Chr1, 6.49 cM
• Alliance: Il17f^tm1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136279
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An frt-flanked puromycin resistance cassette followed by an IRES RFP cassette was inserted into exon 2. Germ line, flp-mediated recombination was used to remove the puro cassette. The absence of protein expression was confirmed by enzyme-linked immunosorbent assay on splenocytes. This is a null allele and a reporter allele. (J:136279)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Il17f^tm1Cdon

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17f Mutation: 28 strains or lines available

References

• Original: J:136279 Yang XO, et al., Regulation of inflammatory responses by IL-17F. J Exp Med. 2008 May 12;205(5):1063-75
• All: 23 reference(s)