Il17a^tm1Cdon
Targeted Allele Detail

Summary

• Symbol: Il17a^tm1Cdon
• Name: interleukin 17A; targeted mutation 1, Chen Dong
• MGI ID: MGI:3796156
• Gene: Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
• Alliance: Il17a^tm1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136279
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 was replaced with a luc/IRES/GFP cassette followed by a floxed neo cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. The absence of protein expression was confirmed by enzyme-linked immunosorbent assay on splenocytes. This is a null allele and a reporter allele. (J:136279)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17a Mutation: 25 strains or lines available

References

• Original: J:136279 Yang XO, et al., Regulation of inflammatory responses by IL-17F. J Exp Med. 2008 May 12;205(5):1063-75
• All: 16 reference(s)