Irak2^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Irak2^tm1Aki
• Name: interleukin-1 receptor-associated kinase 2; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3796171
• Gene: Irak2 Location: Chr6:113615428-113671987 bp, + strand Genetic Position: Chr6, 52.82 cM
• Alliance: Irak2^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136290
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 4 through exon 6 was replaced with a floxed neo cassette. The absence of protein product was confirmed by western blot analysis on macrophage extracts. (J:136290)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irak2 Mutation: 58 strains or lines available

References

• Original: J:136290 Kawagoe T, et al., Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat Immunol. 2008 Jun;9(6):684-91
• All: 4 reference(s)