Camkk2^tm1.1Arm
Targeted Allele Detail

Summary

• Symbol: Camkk2^tm1.1Arm
• Name: calcium/calmodulin-dependent protein kinase kinase 2, beta; targeted mutation 1.1, Anthony R Mean
• MGI ID: MGI:3796172
• Gene: Camkk2 Location: Chr5:122869233-122917472 bp, - strand Genetic Position: Chr5, 62.55 cM
• Alliance: Camkk2^tm1.1Arm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136219
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were floxed and a floxed neo cassette was inserted into the gene. Transient expression of cre in ES cells was used to remove exons 2 through 4 and the neo cassette. The absence of protein product was confirmed by western blot analysis on hypothalamus extracts. (J:136219)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camkk2 Mutation: 42 strains or lines available

References

• Original: J:136219 Anderson KA, et al., Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab. 2008 May;7(5):377-88
• All: 14 reference(s)