Best2^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Best2^tm1Dgen
• Name: bestrophin 2; targeted mutation 1, Deltagen
• MGI ID: MGI:3796232
• Synonyms: Best2^tm1Amar
• Gene: Best2 Location: Chr8:85733831-85741160 bp, - strand Genetic Position: Chr8, 41.46 cM
• Alliance: Best2^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136137
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 containing the translation initiation methionine through part of exon 3 was replaced with a lacZ-neo cassette. The absence of protein product was confirmed by immunohistochemistry of colon and eye tissue. This is a null allele and a reporter allele. (J:136137)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Best2 Mutation: 29 strains or lines available

References

• Original: J:136137 Bakall B, et al., Bestrophin-2 is involved in the generation of intraocular pressure. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1563-70
• All: 6 reference(s)