Sfrp1^tm1Jrbn
Targeted Allele Detail

Summary

• Symbol: Sfrp1^tm1Jrbn
• Name: secreted frizzled-related protein 1; targeted mutation 1, Jeffrey Rubin
• MGI ID: MGI:3796251
• Synonyms: Sfrp1^lacZ, Sfrp1^tm1Pcma
• Gene: Sfrp1 Location: Chr8:23901518-23939648 bp, + strand Genetic Position: Chr8, 11.48 cM
• Alliance: Sfrp1^tm1Jrbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136160
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette was inserted downstream of the initiation methionine codon in exon 1 replacing the endogenous sequence. The absence of protein product was confirmed by western blot analysis on prostate and seminal vesicle extracts. (J:136160)

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sfrp1 Mutation: 19 strains or lines available

References

• Original: J:136160 Joesting MS, et al., Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate. Dev Biol. 2008 May 1;317(1):161-73
• All: 3 reference(s)