Fkbp1b^tm1.1Okam
Targeted Allele Detail

Summary

• Symbol: Fkbp1b^tm1.1Okam
• Name: FK506 binding protein 1b; targeted mutation 1.1, Hiroshi Okamoto
• MGI ID: MGI:3796254
• Gene: Fkbp1b Location: Chr12:4883174-4891591 bp, - strand Genetic Position: Chr12, 2.09 cM
• Alliance: Fkbp1b^tm1.1Okam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136192
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette and exon 1. The absence of protein product was confirmed by western blot analysis on islet extracts. (J:136192)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp1b Mutation: 14 strains or lines available

References

• Original: J:136192 Noguchi N, et al., FKBP12.6 disruption impairs glucose-induced insulin secretion. Biochem Biophys Res Commun. 2008 Jul 11;371(4):735-40
• All: 1 reference(s)