Suz12^Plt8
Chemically induced Allele Detail

Summary

• Symbol: Suz12^Plt8
• Name: SUZ12 polycomb repressive complex 2 subunit; platelet 8
• MGI ID: MGI:3796426
• Synonyms: Suz12^Plat8
• Gene: Suz12 Location: Chr11:79883932-79924949 bp, + strand Genetic Position: Chr11, 47.36 cM
• Alliance: Suz12^Plt8 page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Intragenic deletion
• Mutation details: This mutation was identified by ENU mutagenesis screen performed with Mpl^tm1Wsa homozygous mice to identify mutations that suppress thrombocytopenia and/or stem cell defects. A single base pair deletion disrupting the splice acceptor site upstream of exon 16 causes aberrant transcription resulting in reduced protein products. (J:136262)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Suz12 Mutation: 61 strains or lines available

References

• Original: J:136262 Majewski IJ, et al., Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity. PLoS Biol. 2008 Apr 15;6(4):e93
• All: 2 reference(s)