Tg(Tg-cre)1Soff
Transgene Detail

Summary

• Symbol: Tg(Tg-cre)1Soff
• Name: transgene insertion 1, Stefan Offermanns
• MGI ID: MGI:3796561
• Synonyms: Tg-cre
• Transgene: Tg(Tg-cre)1Soff Location: unknown
• Alliance: Tg(Tg-cre)1Soff page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Tg-cre)1Soff expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tg (MGI:98733)

• Mutation details: A transgenic construct with the coding sequence of the iCre recombinase followed by the bovine GH polyadenylation signal and a frt-flanked ampicillin cassette was fused to sequences from the proximal promoter and first intron of the mouse thyroglobulin (Tg) gene. The whole construct was introduced into the PAC encoding the Tg gene and by homologous recombination, the ATG of the iCre replaced the ATG of the thryoglobulin gene. The ampicillin cassette was removed by Flp-mediated recombination. Cre activity is observed in nearly all thyrocytes, but not in other cells of the thryoid gland after E10.5. (J:127484)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tg (mouse) Summary of all recombinase alleles driven by Tg. Comparative matrix view of recombinase activities Alliance mouse Tg gene page

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cn1	Gna11^tm1Soff/Gna11^tm1Soff Gnaq^tm2Soff/Gnaq^tm2Soff Tg(Tg-cre)1Soff/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
endocrine/exocrine glands	√
endocrine/exocrine gland phenotype	N
abnormal thyroid gland morphology	√
abnormal thyroid follicular cell morphology	√
abnormal thyroid gland physiology	√
decreased activity of thyroid gland	√
homeostasis/metabolism	√
decreased circulating thyroxine level	√
increased circulating thyroid-stimulating hormone level	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127484 Kero J, et al., Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development. J Clin Invest. 2007 Sep;117(9):2399-407
• All: 6 reference(s)