Fzd5^tm2Nat
Targeted Allele Detail

Summary

• Symbol: Fzd5^tm2Nat
• Name: frizzled class receptor 5; targeted mutation 2, Jeremy Nathans
• MGI ID: MGI:3796577
• Synonyms: Fz5^CKO-AP
• Gene: Fzd5 Location: Chr1:64769717-64776907 bp, - strand Genetic Position: Chr1, 32.74 cM
• Alliance: Fzd5^tm2Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136390
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of exon 1 and a cassette containg a 5' loxP site, alkaline phosphatase gene and an frt-flanked neo gene was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed and the alkaline phosphatase gene intact. This is a floxed allele and a reporter allele. (J:136390)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fzd5 Mutation: 33 strains or lines available

References

• Original: J:136390 Liu C, et al., An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus. J Neurosci. 2008 May 28;28(22):5641-53
• All: 6 reference(s)