Setd7^tm1Frga
Targeted Allele Detail

Summary

• Symbol: Setd7^tm1Frga
• Name: SET domain containing (lysine methyltransferase) 7; targeted mutation 1, Francois Gaudet
• MGI ID: MGI:3796607
• Gene: Setd7 Location: Chr3:51422740-51468300 bp, - strand Genetic Position: Chr3, 22.5 cM
• Alliance: Setd7^tm1Frga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136558
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZ/neo cassette. The absence of protein product was confirmed by western blot analysis. This is a null allele and a reporter allele. (J:136558)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd7 Mutation: 29 strains or lines available

References

• Original: J:136558 Kurash JK, et al., Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Mol Cell. 2008 Feb 15;29(3):392-400
• All: 4 reference(s)