Smtnl1^tm1Tajh
Targeted Allele Detail

Summary

• Symbol: Smtnl1^tm1Tajh
• Name: smoothelin-like 1; targeted mutation 1, Timothy A J Haystead
• MGI ID: MGI:3796616
• Gene: Smtnl1 Location: Chr2:84641520-84652996 bp, - strand Genetic Position: Chr2, 49.45 cM, cytoband E1
• Alliance: Smtnl1^tm1Tajh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136573
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 8, which encode amino acids 230-421, were replaced with a neo cassette. The absence of protein product was confirmed by western blot on skeletal muscle extracts. (J:136573)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smtnl1 Mutation: 20 strains or lines available

References

• Original: J:136573 Wooldridge AA, et al., Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008 Apr 25;283(17):11850-9
• All: 4 reference(s)