Plk3^tm1Dai
Targeted Allele Detail

Summary

• Symbol: Plk3^tm1Dai
• Name: polo like kinase 3; targeted mutation 1, Wei Dai
• MGI ID: MGI:3796743
• Gene: Plk3 Location: Chr4:116985852-116991160 bp, - strand Genetic Position: Chr4, 53.41 cM
• Alliance: Plk3^tm1Dai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136425
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 8 were replaced with a neo cassette. The absence of transcript was confirmed but quantitative PCR on heart extracts. (J:136425)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Plk3^tm1Dai

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plk3 Mutation: 34 strains or lines available

References

• Original: J:136425 Yang Y, et al., Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res. 2008 Jun 1;68(11):4077-85
• All: 4 reference(s)