Ncstn^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Ncstn^tm1.1Sud
• Name: nicastrin; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:3796837
• Synonyms: fnicastrin
• Gene: Ncstn Location: Chr1:171893580-171910356 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Ncstn^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149506
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette, flanked by loxP and Frt sites was introduced to intron 2 and an additional loxP site was placed in intron 3 of the nicastrin gene. Germ line, flp mediated recombination removed the neo cassette. (J:149506)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncstn Mutation: 34 strains or lines available

References

• Original: J:149506 Tabuchi K, et al., Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci. 2009 Jun 3;29(22):7290-301
• All: 5 reference(s)