Rr148^tm1Anbo
Targeted Allele Detail

Summary

• Symbol: Rr148^tm1Anbo
• Name: regulatory region 148; targeted mutation 1, Andrea Bottaro
• MGI ID: MGI:3796983
• Synonyms: deltaEmu, Igh^tm1Anbo
• Gene: Rr148 Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Rr148^tm1Anbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136307
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The core Emu enhancer element, located between the Igh J and Cmu gene segments, was replaced by a loxP site flanked neomycin resistance gene cassette. Germ line, cre-mediated recombination was used to remove the neo cassette. (J:136307)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr148 Mutation: 0 strains or lines available

Notes

ES cell line = F1.11

References

• Original: J:136307 Kuzin II, et al., Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation. J Immunol. 2008 Jun 1;180(11):7443-50
• All: 1 reference(s)