Foxc1^hith
Chemically induced Allele Detail

Summary

• Symbol: Foxc1^hith
• Name: forkhead box C1; hole-in-the-head
• MGI ID: MGI:3797008
• Synonyms: Foxc1^line351, m351Asp
• Gene: Foxc1 Location: Chr13:31990629-31994618 bp, + strand Genetic Position: Chr13, 13.52 cM
• Alliance: Foxc1^hith page

Eye, skull, and brain abnormalities in Foxc1^hith/Foxc1^hith mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutatgenesis induced a T to C transition resulting in an amino acid substitution of phenylalanine with leucine at position 107 (F107L). This mutation occurs in the DNA binding forkhead domain. (J:136459)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc1 Mutation: 29 strains or lines available

References

• Original: J:136795 Zarbalis K, et al., A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol. 2004 Aug;2(8):E219
• All: 9 reference(s)