Tnfsf15^tm1Cdon
Targeted Allele Detail

Summary

• Symbol: Tnfsf15^tm1Cdon
• Name: tumor necrosis factor (ligand) superfamily, member 15; targeted mutation 1, Chen Dong
• MGI ID: MGI:3797013
• Synonyms: TL1A^-
• Gene: Tnfsf15 Location: Chr4:63642837-63663296 bp, - strand Genetic Position: Chr4, 34.06 cM
• Alliance: Tnfsf15^tm1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136280
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with neo cassette by targeted homologous recombination. The absence of expression was confirmed by RT-PCR on kidney tissues previously shown to express high levels of the transcripts. This is a null allele. (J:136280)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf15 Mutation: 21 strains or lines available

References

• Original: J:136280 Pappu BP, et al., TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med. 2008 May 12;205(5):1049-62
• All: 3 reference(s)