Bmp4^tm4Blh
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm4Blh
• Name: bone morphogenetic protein 4; targeted mutation 4, Brigid L Hogan
• MGI ID: MGI:3797048
• Synonyms: Bmp4^loxP
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm4Blh page

Hindlimb fusion of Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136636
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into introns 2 and 4. An frt-flanked neo cassette used for selection was removed by germ line, flp-mediated recombination. (J:136636)

Disease models

Expression

In Mice Carrying this Mutation:	62 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 23 strains or lines available

References

• Original: J:136636 Chang W, et al., Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet. 2008 Apr;4(4):e1000050
• All: 19 reference(s)