Il7^m1Jyen
Chemically induced Allele Detail

Summary

• Symbol: Il7^m1Jyen
• Name: interleukin 7; mutation 1, Jeffrey Jong-Young Yen
• MGI ID: MGI:3797070
• Synonyms: deltaE3-IL7
• Gene: Il7 Location: Chr3:7637088-7678820 bp, - strand Genetic Position: Chr3, 2.02 cM
• Alliance: Il7^m1Jyen page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis led to a G-to-A point mutation in the splicing donor site of the third exon of the gene locus. This mutation resulted in skipping of exon 3 during transcription and production of a internally truncated transcript that potentially encodes a polypeptide that lacks sequence from aspartic acid-49 to lysine-75. RT-PCR confirmed the presence of a truncated mRNA. This is considered a hypomorph allele. (J:136470)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il7 Mutation: 33 strains or lines available

References

• Original: J:136470 Huang HW, et al., An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis. J Biomed Sci. 2007 Mar;14(2):169-81
• All: 1 reference(s)