Flrt3^tm1Rob
Targeted Allele Detail

Summary

• Symbol: Flrt3^tm1Rob
• Name: fibronectin leucine rich transmembrane protein 3; targeted mutation 1, Elizabeth J Robertson
• MGI ID: MGI:3797077
• Gene: Flrt3 Location: Chr2:140500118-140513396 bp, - strand Genetic Position: Chr2, 69.2 cM
• Alliance: Flrt3^tm1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136719
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A gene trapping vector containing a beta-geo cassette was targeted by homologous recombination into intron 2. The absence of protein product was confirmed by western blot analysis on brain extracts. This is a null allele and a reporter allele. (J:136719)

Expression

In Mice Carrying this Mutation:	78 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flrt3 Mutation: 44 strains or lines available

References

• Original: J:136719 Maretto S, et al., Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 2008 Jun 1;318(1):184-93
• All: 2 reference(s)