Ccne1^tm1Clur
Targeted Allele Detail

Summary

• Symbol: Ccne1^tm1Clur
• Name: cyclin E1; targeted mutation 1, Bruce E Clurman
• MGI ID: MGI:3797100
• Synonyms: E^{T74A T393A}
• Gene: Ccne1 Location: Chr7:37797409-37806915 bp, - strand Genetic Position: Chr7, 25.35 cM
• Alliance: Ccne1^tm1Clur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A contruct carrying a threonine to alanine amino acid substitution at positions 74 and 393 was knocked into the locus. A floxed neo cassette used for selection was removed by germ line, cre-mediated recombination. (J:136692)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccne1 Mutation: 23 strains or lines available

References

• Original: J:136692 Minella AC, et al., Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev. 2008 Jun 15;22(12):1677-89
• All: 5 reference(s)