Krt19^{tm1(cre/ERT)Ggu}
Targeted Allele Detail

Summary

• Symbol: Krt19^{tm1(cre/ERT)Ggu}
• Name: keratin 19; targeted mutation 1, Guoqiang Gu
• MGI ID: MGI:3797107
• Synonyms: CK19-CreER, CK19^CreERT, K19CreER, Krt19-CreER^T, Krt19^{tm1(cre/ESR1)Ggu}
• Gene: Krt19 Location: Chr11:100031636-100036752 bp, - strand Genetic Position: Chr11, 63.42 cM
• Alliance: Krt19^{tm1(cre/ERT)Ggu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136694
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Krt19^{tm1(cre/ERT)Ggu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt19 (MGI:96693)

• Mutation details: An inducible cre/ESR1 fusion gene followed by an frt-flanked neo cassette was inserted upstream of the translation initiation codon. Cre expression is restricted to epithelial cells in multiple endodermal organs (pancreatic ducts, hepatic ducts, stomach and intestine). (J:136694)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt19 (mouse) Summary of all recombinase alleles driven by Krt19. Comparative matrix view of recombinase activities Alliance mouse Krt19 gene page

Tumor Data

List all tumor models in MMHCdb carrying Krt19^{tm1(cre/ERT)Ggu}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Krt19 Mutation: 21 strains or lines available

References

• Original: J:136694 Means AL, et al., A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis. 2008 Jun;46(6):318-23
• All: 72 reference(s)