Mapt^{tm3(cre/PGR)Aha}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm3(cre/PGR)Aha}
• Name: microtubule-associated protein tau; targeted mutation 3, Akihiro Harada
• MGI ID: MGI:3797111
• Synonyms: tau^CrePR
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm3(cre/PGR)Aha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136624
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Mapt^{tm3(cre/PGR)Aha} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mapt (MGI:97180)

• Mutation details: An inducible cre/PGR (progesterone receptor) fusion gene followed by a neo cassette was inserted upstream of exon 1. Cre expression is neuron specific. (J:136624)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mapt (mouse) Summary of all recombinase alleles driven by Mapt. Comparative matrix view of recombinase activities Alliance mouse Mapt gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:136624 Hashimoto Y, et al., Neuron-specific and inducible recombination by Cre recombinase in the mouse. Neuroreport. 2008 Apr 16;19(6):621-4
• All: 2 reference(s)